Why Cellular Resilience Matters and How NAD⁺ Plays a Part
At INORA, we believe true wellness starts at the cellular level. When every cell thrives, your body becomes more resilient, your energy more consistent, and your ageing process more graceful.
What Is Inflammaging?
Every second, our cells work to produce energy, repair DNA, and maintain balance. But chronic stress, limited sleep, and low grade inflammation wear down these processes over time, a phenomenon known as inflammaging.
This subtle, chronic inflammation differs from the body’s acute immune response. Over years, inflammaging contributes to reduced metabolic efficiency, slower repair, and declining cellular resilience (Furman et al., 2019; Calder et al., 2017).
NAD⁺ The Cellular Powerhouse
Inside every cell, a molecule called nicotinamide adenine dinucleotide (NAD⁺) plays a central role. Think of it as a vital hub:
• It helps convert nutrients into usable energy
• It activates sirtuins, proteins deeply involved in DNA repair and cellular upkeep
• It delivers signals to coordinate how a cell responds to damage or stress (López Otín et al., 2013)
What Happens When NAD⁺ Declines
With ageing, stress, or inflammation, NAD⁺ levels naturally drop. As this happens:
• Energy production becomes less efficient
• DNA repair and recovery slow down
• Cells become more vulnerable to wear and damage
Supporting healthy NAD⁺ pathways helps maintain cellular resilience, reduce inflammatory stress, and sustain essential repair functions (Iqbal et al., 2024).
How to Support Cellular Balance
Boosting NAD⁺ is not about defying age but about giving your cells the tools to do their job well. Here’s how to support them:
• Nutrition: Focus on whole foods, polyphenol rich plants, and nutrients that support NAD⁺ metabolism
• Restorative Sleep: Deep, consistent rest is foundational for repair
• Stress Management: Chronic stress is a major drain on cellular systems
• Targeted Support: NAD⁺ precursors or formulations designed to support healthy NAD⁺ pathways
By supporting your cells’ ability to renew and repair, you build a foundation for lasting wellness and vitality.
References
1. Furman, D., et al. (2019). Chronic inflammation in the etiology of disease across the life span. Nature Medicine.
2. Calder, P. C., Bosco, N., Bourdet Sicard, R., et al. (2017). Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition. Ageing Research Reviews.
3. López Otín, C., et al. (2013). The Hallmarks of Ageing. Cell.
4. Iqbal, S., et al. (2024). The therapeutic perspective of NAD⁺ precursors in age related diseases. Biochemical and Biophysical Research Communications.